With wife and children in tow, Douthat prices real estate in Connecticut. He plays the house-hunting scenes to good comic effect, consistently the butt of his own jokes and always just slightly funnier than he is insufferable ... For the rest of the book, Douthat artfully weaves two stories together. The first is the story of his own illness, the increasingly outlandish treatments he is willing to try, and the havoc the affliction wreaks in his life. As he looks for a cure, he uncovers a second story: the strange tale of Lyme disease itself ... The story of the medical establishment’s skepticism is interesting, but due to the high profile of long COVID, all but the dullest physicians will have realized by now that conditions like chronic fatigue and Lyme are real. The true heart of the book is Douthat’s narrative of his personal illness. No two chronic illnesses are exactly alike, but even so this book will likely resonate with anyone who has suffered from a chronic condition or has cared for someone who has.
Douthat sees symbols everywhere; he is telling a story not only of his own illness, but also about the stories we tell ourselves, secular and religious, to make sense of illness. This makes him a self-aware narrator. He knows he has resources many suffering patients don’t — including the benefit of the doubt not afforded the older women who tend to report chronic Lyme symptoms ... Writhing in pain on the bathroom floor, breaking down halfway through a speech or stumbling into empty churches to pray for relief, Douthat lays himself bare in ways that can be affecting. He is no braver for sharing his story than the women who have written Lyme memoirs before him...Still, in today’s hypermasculine conservative culture — where illness is a sign of weakness — this book is a near-radical act of humility. He makes his case that tick-borne disease needs more research and its sufferers deserve more respect ... The trouble is that Douthat also wants to present his reckless journey as a road map ... That this 'I’ll do my own research; sentiment is of the moment does not make it less damaging. On the contrary, a pandemic is the least helpful time to argue for the primacy of patient-designed protocols and internet anecdotes over actual science — imperfect, slow and unfeeling as it may be. Even in 2021, not everyone is an epidemiologist.
In educative chapters that describe the speculated origins and chronology of the resilient disease, Douthat maps out just how elusive accurate treatment can become and how the road to a definitive diagnosis can drag on through years of antibiotic trials. Consistently candid and often harrowing, Douthat’s eloquent prose injects shimmers of possibility into the seemingly hopeless situation he was forced to endure. As with many Lyme disease accounts, there is no happy ending nor a resounding diagnosis and effective treatment eradicating it from the lives of sufferers. The author’s persistence in conquering Lyme disease’s 'impenetrable-seeming wall of opposition and denial' bleeds across each page. Douthat’s explorations of bioweaponized theories for Lyme’s origins are unconvincing, but they don’t ruin the impact of his message ... A palpable patient experience of a pervasive disease that continues to confound medical science.